The Quail Lab is focused on the role of the tumour microenvironment during cancer progression, with a particular interest in tumour immunology and myeloid-targeted immunotherapies. Our team is investigating 3 major themes: (1) How do chronic inflammatory conditions, such as obesity, promote cancer progression? (2) What shapes the immune landscape in tumours, and how does this dictate response to treatment? (3) How does the microenvironment affect tumour progression within an immune privileged tissue, such as brain? To study the tumour microenvironment, we use cutting edge technologies such as highly-multiplexed imaging mass cytometry, intravital microscopy, spectral flow cytometry, single cell sequencing, and genetically-engineered in vivo models.

Tonsil IMC image
Mass cytometry image of a tonsil germinal centre. Single Cell and Imaging Mass Cytometry Platform, GCI; image by Nick Bennett.
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